A Study of PartySharp in Prevention of Hangover and in Elimination of Acetaldehyde

High alcohol consumption or chronic drinking results in alcohol habituation and alters the psychological and physical well-being of the individual. The various clinical problems that can arise from excess drinking are multiple such as high in blood pressure, headache, digestive disturbances, anxiety and depression, sleep irregularities, sexual difficulties, poor concentration and work performance, liver disease and hangover. The hangover effects manifesting as headache, irritability, nervous tension, depression, tremors are carried over sometimes even after 24 hours after drinking. These symptoms can affect individual performance physically as well as mentally. The study conducted in patients with the history of chronic alcoholism with oral administration of PartySharp capsules administered at the dose of two capsules before the consumption of alcohol have shown that PartySharp prevents the symptoms of hangover by stimulating the metabolism of alcohol. INTRODUCTION Hangover from consuming alcohol affect people of all walks of life. Personality disorders and drinking problems correlate significantly with subjects who experience hangover (Earleywine M. 1993). Alcoholics often have poor sleep during periods of abstinence, during episodes of heavy drinking and during withdrawal from alcohol (Aldrich M.S. 1998). The carryover effects or the hangover hypothesis postulates that alcohol continues to impair performance the morning after drinking, even after low or moderate doses (Finnigan F., Hammersley R. and Cooper T. 1998). Hangover affects the cognitive functions and physical performance in individuals particularly working on machinery and handling aircraft and other heavy vehicles (Moore R.S. 1998). Many herbal drugs help in the prevention of liver damage from hepatotoxic agents such as ethanol by producing hepatoprotective effect (Chattopadhyay, R.R. et al. 1992, Dwivedi, Y. et al.). Some of the herbs also help in the elimination of ethanol and acetaldehyde from the body (Chauhan, B.L. and Kulkarni, R.D. 1991). Keeping the above facts, a Phase II study with a herbal formulation known as PartySharp, which has been known to rapidly eliminate ethanol in two stages, was undertaken. In the 1 stage, prevention of hangover by helping in the rapid elimination of ethanol was done. In the 2 stage a study was undertaken to study the pharmacokinetics of this formulation. PartySharp is an herbal formulation comprising of